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How is ELELYSO made?

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How is ELELYSO made?

ELELYSO® (taliglucerase alfa) for injection is made by the Israeli biotherapeutics company Protalix.

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First-of-its-kind technology

 

Here are some features of plant cell-based technology:

ELELYSO is plant based

ELELYSO is made by growing the enzyme glucocerebrosidase inside carrot cells. The growth medium used is made from sucrose, vitamins, minerals, and water.

Production is expandable

ELELYSO is also made at a dedicated manufacturing site. The plant cell-based production system uses multiple 800-liter disposable bioreactors (the vats that ELELYSO is made in). Bioreactors can be easily added to increase ELELYSO supply as needed.

Active enzyme molecules

These enzymes are naturally able to enter Gaucher cells without any chemical alterations. These enzymes naturally have a uniform structure that is reproducible and consistent from batch to batch.

ELELYSO supply

  • To help minimize supply disruptions, Pfizer regularly monitors US patient count as part of the demand and supply planning process for ELELYSO
  • Due to the first-of-its-kind technology, ProCellEx protein expression system, Pfizer can scale production and increase supply as needed

*ProCellEx is a registered trademark of Protalix Biotherapeutics.

Protalix: an Israeli-based biotechnology company

Even though Gaucher disease is a rare disease, it is familiar to the employees of Protalix Biotherapeutics, an Israeli-based biotech company. Several have family members and friends who have personal experience with Gaucher disease, so the employees truly understand the impact it can have on patients and their families. Out of their passion to help people, ELELYSO was developed as a treatment for Type 1 Gaucher disease.

*ProCellEx is a registered trademark of Protalix Biotherapeutics.

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